DutasterideAd id : 3461
Price : Please contact
Date listed : 2018-Jul-09


Dutasteride, medical drug, white or off-white crystalline powder. Adaptation symptoms: enlarged prostate, male pattern hair loss, seborrheic alopecia, hereditary alopecia (women and children should not take it). Note: Do not donate blood or let women become pregnant during the medication and within 6 months after stopping the drug.

Chinese name Dutasteride
CAS NO.164656-23-9
English name Dutasteride
Molecular formula C27H30F6N2O2
Molecular weight 528.53
Dutasteride is a white to pale yellow powder with a melting point of 242-250 ° C, insoluble in water, soluble in ethanol (44 mg/ml), methanol (64 mg/ml), and polyethylene glycol 400 (4 mg/ml).


Dutasteride use and synthesis
Treatment of benign prostatic hyperplasia drugs On October 9, 2002, the United States Food and Drug Administration approved a new drug, tacrolimus, developed by GlaxoSmithKline for the treatment of prostate enlargement.
On June 19, 2008, GlaxoSmithKline announced that the US FDA approved the combination of dutasteride (Avodart) and tamsulosin (Harnal) for the treatment of benign prostatic hyperplasia.
In China, every two older men over the age of 60 have a benign prostatic hyperplasia that can cause lower urinary tract symptoms, including a significant increase in urination frequency, weak urinary flow, difficulty in emptying the bladder, and nocturia, even including acute Serious complications such as urinary retention reduce the quality of life of patients and affect social life.
Dutasteride is the first and only dual 5α reductase inhibitor for the treatment of benign prostatic hyperplasia, which can improve urinary symptoms, reduce acute urinary retention and risk associated with prostate surgery. Tamsulosin is an alpha receptor blocker that improves the symptoms of benign prostatic hyperplasia.
There are two type 5α reductases of type I and type II in the human body. Type II is mainly present in the prostate, and type I is mainly distributed in the liver and skin. 5α reductase is an important cause of the progression of benign prostatic hyperplasia, which can promote the conversion of testosterone in the prostate to the more active dihydrotestosterone, leading to the proliferation of prostate cells and hypertrophy of the prostate. Therefore, the key to treating benign prostatic hyperplasia is to inhibit 5α reductase. And dutasteride can inhibit both type I and type II 5α reductase. Through this 'double inhibition' mechanism, dutasteride can rapidly and continuously reduce prostate volume, significantly improve lower urinary tract symptoms and reduce acute urinary retention. And the risk of prostate surgery, the patient's long-term benefits, especially in the majority of patients with moderate to severe benign prostatic hyperplasia.
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